High-resolution and high-accuracy topographic and transcriptional maps of the nucleosome barrier

High-resolution and high-accuracy topographic and transcriptional maps of the nucleosome barrier

Nucleosomes represent mechanical and energetic barriers that RNA Polymerase II (Pol II) must overcome during transcription. A high-resolution description of the barrier topography, its modulation by epigenetic modifications, and their effects on Pol II nucleosome crossing dynamics, is still missing....

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Bibliographic Details
Main Authors: Zhijie Chen, Ronen Gabizon, Aidan I Brown, Antony Lee, Aixin Song, César Díaz-Celis, Craig D Kaplan, Elena F Koslover, Tingting Yao, Carlos Bustamante
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-07-01
Series:eLife
Subjects:
nucleosome transcription
high-resolution optical tweezers
histone variant H2A.Z
epigenetic modifications
histone ubiquitination
transcription regulation
Online Access:https://elifesciences.org/articles/48281

Internet

https://elifesciences.org/articles/48281

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