HDAC2- and EZH2-Mediated Histone Modifications Induce PDK1 Expression through miR-148a Downregulation in Breast Cancer Progression and Adriamycin Resistance

HDAC2- and EZH2-Mediated Histone Modifications Induce PDK1 Expression through miR-148a Downregulation in Breast Cancer Progression and Adriamycin Resistance

Background: Breast cancer has one of highest morbidity and mortality rates for women. Abnormalities regarding epigenetics modification and pyruvate dehydrogenase kinase 1 (PDK1)-induced unusual metabolism contribute to breast cancer progression and chemotherapy resistance. However, the role and mech...

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Bibliographic Details
Main Authors: Yunxia Xie, Zhumei Shi, Yingchen Qian, Chengfei Jiang, Wenjing Liu, Bingjie Liu, Binghua Jiang
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cancers
Subjects:
PDK1
epigenetic modification
miR-148a
breast cancer
Adriamycin resistance
Online Access:https://www.mdpi.com/2072-6694/14/15/3600

Internet

https://www.mdpi.com/2072-6694/14/15/3600

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