Chemical Modification of Pactamycin Leads to New Compounds with Retained Antimicrobial Activity and Reduced Toxicity

Chemical Modification of Pactamycin Leads to New Compounds with Retained Antimicrobial Activity and Reduced Toxicity

Pactamycin (PCT), an antibiotic produced by <i>Streptomyces pactum</i>, is a five-membered ring aminocyclitol that is active against a variety of Gram-positive and Gram-negative microorganisms, as well as several animal tumor lines in culture and in vivo. Pactamycin targets the small rib...

Full description

Bibliographic Details
Main Authors: Artemis Tsirogianni, Nikolina Ntinou, Konstantina Karampatsou, George Dinos, Georgia G. Kournoutou, Constantinos M. Athanassopoulos
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Molecules
Subjects:
antibiotics
pactamycin
protein synthesis
Online Access:https://www.mdpi.com/1420-3049/29/17/4169

Internet

https://www.mdpi.com/1420-3049/29/17/4169

Similar Items