Modulation of Multiple Gene Clusters’ Expression by the PAS-LuxR Transcriptional Regulator PteF

Modulation of Multiple Gene Clusters’ Expression by the PAS-LuxR Transcriptional Regulator PteF

PAS-LuxR transcriptional regulators are conserved proteins governing polyene antifungal biosynthesis. PteF is the regulator of filipin biosynthesis from <i>Streptomyces avermitilis</i>. Its mutation drastically abates filipin, but also oligomycin production, a macrolide ATP-synthase inhi...

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Bibliographic Details
Main Authors: Cláudia M. Vicente, Tamara D. Payero, Antonio Rodríguez-García, Eva G. Barreales, Antonio de Pedro, Fernando Santos-Beneit, Jesús F. Aparicio
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Antibiotics
Subjects:
antifungal agent
gene regulation
LuxR
PAS domain
polyene macrolide
<i>Streptomyces</i>
Online Access:https://www.mdpi.com/2079-6382/11/8/994

Internet

https://www.mdpi.com/2079-6382/11/8/994

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