Modulation of Multiple Gene Clusters’ Expression by the PAS-LuxR Transcriptional Regulator PteF

Modulation of Multiple Gene Clusters’ Expression by the PAS-LuxR Transcriptional Regulator PteF

PAS-LuxR transcriptional regulators are conserved proteins governing polyene antifungal biosynthesis. PteF is the regulator of filipin biosynthesis from <i>Streptomyces avermitilis</i>. Its mutation drastically abates filipin, but also oligomycin production, a macrolide ATP-synthase inhi...

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Bibliographic Details
Main Authors:	Cláudia M. Vicente, Tamara D. Payero, Antonio Rodríguez-García, Eva G. Barreales, Antonio de Pedro, Fernando Santos-Beneit, Jesús F. Aparicio
Format:	Article
Language:	English
Published:	MDPI AG 2022-07-01
Series:	Antibiotics
Subjects:	antifungal agent gene regulation LuxR PAS domain polyene macrolide <i>Streptomyces</i>
Online Access:	https://www.mdpi.com/2079-6382/11/8/994

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