Essentiality and Transcriptome-Enriched Pathway Scores Predict Drug-Combination Synergy

Essentiality and Transcriptome-Enriched Pathway Scores Predict Drug-Combination Synergy

In the prediction of the synergy of drug combinations, systems pharmacology models expand the scope of experiment screening and overcome the limitations of current computational models posed by their lack of mechanical interpretation and integration of gene essentiality. We therefore investigated th...

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Bibliographic Details
Main Authors: Jin Li, Yang Huo, Xue Wu, Enze Liu, Zhi Zeng, Zhen Tian, Kunjie Fan, Daniel Stover, Lijun Cheng, Lang Li
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Biology
Subjects:
drug-combination synergy prediction
drug target
gene essentiality
gene expression
KEGG pathway
Online Access:https://www.mdpi.com/2079-7737/9/9/278

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https://www.mdpi.com/2079-7737/9/9/278

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