Macrophage‐specific hypoxia‐inducible factor‐1α deletion suppresses the development of liver tumors in high‐fat diet‐fed obese and diabetic mice

Macrophage‐specific hypoxia‐inducible factor‐1α deletion suppresses the development of liver tumors in high‐fat diet‐fed obese and diabetic mice

Abstract Aims/Introduction Chronic inflammation of the liver is often observed with obesity or type 2 diabetes. In these pathological conditions, the immunological cells, such as macrophages, play important roles in the development or growth of liver cancer. Recently, it was reported that hypoxia‐in...

Full description

Bibliographic Details
Main Authors: Akiko Takikawa, Isao Usui, Shiho Fujisaka, Koichi Tsuneyama, Keisuke Okabe, Takashi Nakagawa, Allah Nawaz, Tomonobu Kado, Teruo Jojima, Yoshimasa Aso, Yoshihiro Hayakawa, Kunikimi Yagi, Kazuyuki Tobe
Format: Article
Language:English
Published: Wiley 2019-11-01
Series:Journal of Diabetes Investigation
Subjects:
Hypoxia‐inducible factor‐1α
Liver cancer
Macrophage
Online Access:https://doi.org/10.1111/jdi.13047

Internet

https://doi.org/10.1111/jdi.13047

Similar Items