Quest for the Molecular Basis of Improved Selective Toxicity of <i>All-Trans</i> Isomers of Aromatic Heptaene Macrolide Antifungal Antibiotics

Quest for the Molecular Basis of Improved Selective Toxicity of <i>All-Trans</i> Isomers of Aromatic Heptaene Macrolide Antifungal Antibiotics

Three aromatic heptaene macrolide antifungal antibiotics, Candicidin D, Partricin A (Gedamycin) and Partricin B (Vacidin) were subjected to controlled <i>cis-trans</i><i>→ all trans</i> photochemical isomerization. The obtained <i>all-trans</i> isomers demonstrate...

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Bibliographic Details
Main Authors: Julia Borzyszkowska-Bukowska, Justyna Górska, Paweł Szczeblewski, Tomasz Laskowski, Iwona Gabriel, Jakub Jurasz, Katarzyna Kozłowska-Tylingo, Piotr Szweda, Sławomir Milewski
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
aromatic polyene antifungals
selective toxicity
molecular modelling
Online Access:https://www.mdpi.com/1422-0067/22/18/10108

Internet

https://www.mdpi.com/1422-0067/22/18/10108

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