Formulation of Glibenclamide proniosomes for oral administration: Pharmaceutical and pharmacodynamics evaluation

Formulation of Glibenclamide proniosomes for oral administration: Pharmaceutical and pharmacodynamics evaluation

Glibenclamide (GB), oral antidiabetic sulfonylurea, is used in the management of diabetes mellitus type II. It suffers from low bioavailability due to low water solubility. This work aimed to enhance the dissolution of GB by formulating the drug as a proniosomes which then improves the pharmacologic...

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Bibliographic Details
Main Authors: Doaa Alshora, Mohamed Ibrahim, Nouf Alanazi, Malak Alowyid, Zainab Ali Alnakhli, Noura Mohammed Alshiban, Saleh Maodaa, Nouf M. Alyami, Ibrahim Alotaibi
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Saudi Pharmaceutical Journal
Subjects:
Glibenclamide
Proniosomes
UPLC method
Pharmacodynamics study
Dissolution enhancement
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016423003250

Internet

http://www.sciencedirect.com/science/article/pii/S1319016423003250

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