Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases

Over the past 20 years, the concept of mammalian autophagy as a nonselective degradation system has been repudiated, due in part to important discoveries in neurodegenerative diseases, which opened the field of selective autophagy. Protein aggregates and damaged mitochondria represent key pathologic...

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Bibliographic Details
Main Author: Charleen T. Chu
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118302754