Activation of Endothelial Large Conductance Potassium Channels Protects against TNF-α-Induced Inflammation

Activation of Endothelial Large Conductance Potassium Channels Protects against TNF-α-Induced Inflammation

Elevated TNF-α levels in serum and broncho-alveolar lavage fluid of acute lung injury patients correlate with mortality rates. We hypothesized that pharmacological plasma membrane potential (Em) hyperpolarization protects against TNF-α-induced CCL-2 and IL-6 secretion from human pulmonary endothelia...

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Bibliographic Details
Main Authors: Tatiana Zyrianova, Kathlyn Zou, Benjamin Lopez, Andy Liao, Charles Gu, Riccardo Olcese, Andreas Schwingshackl
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
lung inflammation
TNF-α
large conductance K<sup>+</sup> channels
L-type voltage-gated Ca<sup>2+</sup> channels
Nifedipine
NS1619
Online Access:https://www.mdpi.com/1422-0067/24/4/4087

Internet

https://www.mdpi.com/1422-0067/24/4/4087

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