The Acetylcholine-Activated Potassium Current Inhibitor XAF-1407 Terminates Persistent Atrial Fibrillation in Goats

The Acetylcholine-Activated Potassium Current Inhibitor XAF-1407 Terminates Persistent Atrial Fibrillation in Goats

Aims: The acetylcholine-activated inward rectifier potassium current (IKACh) has been proposed as an atrial-selective target for the treatment of atrial fibrillation (AF). Using a novel selective IKACh inhibitor XAF-1407, the study investigates the effect of IKACh inhibition in goats with pacing-ind...

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Bibliographic Details
Main Authors: Vladimír Sobota, Giulia Gatta, Arne van Hunnik, Iris van Tuijn, Marion Kuiper, James Milnes, Thomas Jespersen, Ulrich Schotten, Sander Verheule
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
atrial fibrillation
acetylcholine-activated potassium channel
cardioversion
mapping
remodeling
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.608410/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.608410/full

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