Serum Response Factor (SRF) Drives the Transcriptional Upregulation of the MDM4 Oncogene in HCC

Serum Response Factor (SRF) Drives the Transcriptional Upregulation of the MDM4 Oncogene in HCC

Different molecular mechanisms support the overexpression of the mouse double minute homolog 4 (MDM4), a functional p53 inhibitor, in human hepatocellular carcinoma (HCC). However, the transcription factors (TFs) leading to its transcriptional upregulation remain unknown. Following promoter and gene...

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Bibliographic Details
Main Authors: Rossella Pellegrino, Abhishek Thavamani, Diego F. Calvisi, Jan Budczies, Ariane Neumann, Robert Geffers, Jasmin Kroemer, Damaris Greule, Peter Schirmacher, Alfred Nordheim, Thomas Longerich
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
HCC
MDM4
ELK1
ELK4
ETS transcription factors
ERK
Online Access:https://www.mdpi.com/2072-6694/13/2/199

Internet

https://www.mdpi.com/2072-6694/13/2/199

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