<i>Moringa oleifera</i> Lam. Isothiocyanate Quinazolinone Derivatives Inhibit U251 Glioma Cell Proliferation through Cell Cycle Regulation and Apoptosis Induction

<i>Moringa oleifera</i> Lam. Isothiocyanate Quinazolinone Derivatives Inhibit U251 Glioma Cell Proliferation through Cell Cycle Regulation and Apoptosis Induction

A major active constituent of <i>Moringa oleifera</i> Lam. is 4-[(α-L-rhamnose oxy) benzyl] isothiocyanate (MITC). To broaden MITC’s application and improve its biological activity, we synthesized a series of MITC quinazolinone derivatives and evaluated their anticancer activity. The ant...

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Bibliographic Details
Main Authors: Jing Xie, Ming-Rong Yang, Xia Hu, Zi-Shan Hong, Yu-Ying Bai, Jun Sheng, Yang Tian, Chong-Ying Shi
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Moringa oleifera</i> Lam. isothiocyanate
quinazolinone
glioma U251 cells
apoptosis
cell cycle
Online Access:https://www.mdpi.com/1422-0067/24/14/11376

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https://www.mdpi.com/1422-0067/24/14/11376

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