DNA sequence-selective G-A cross-linking ADC payloads for use in solid tumour therapies
A class of Cyclopropabenzindole-Pyridinobenzodiazepine (CBI-PDD) DNA cross-linking payloads, used in Antibody-Drug Conjugates, alkylate guanine and adenine bases in the DNA minor groove with a defined sequence selectivity.
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03633-0 |