DNA sequence-selective G-A cross-linking ADC payloads for use in solid tumour therapies
A class of Cyclopropabenzindole-Pyridinobenzodiazepine (CBI-PDD) DNA cross-linking payloads, used in Antibody-Drug Conjugates, alkylate guanine and adenine bases in the DNA minor groove with a defined sequence selectivity.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03633-0 |
| _version_ | 1818018631689175040 |
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| author | George Procopiou Paul J. M. Jackson Daniella di Mascio Jennifer L. Auer Chris Pepper Khondaker Miraz Rahman Keith R. Fox David E. Thurston |
| author_facet | George Procopiou Paul J. M. Jackson Daniella di Mascio Jennifer L. Auer Chris Pepper Khondaker Miraz Rahman Keith R. Fox David E. Thurston |
| author_sort | George Procopiou |
| collection | DOAJ |
| description | A class of Cyclopropabenzindole-Pyridinobenzodiazepine (CBI-PDD) DNA cross-linking payloads, used in Antibody-Drug Conjugates, alkylate guanine and adenine bases in the DNA minor groove with a defined sequence selectivity. |
| first_indexed | 2024-04-14T07:41:19Z |
| format | Article |
| id | doaj.art-5745b8e61aa3408ca18a41c49e313d1d |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-14T07:41:19Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-5745b8e61aa3408ca18a41c49e313d1d2022-12-22T02:05:28ZengNature PortfolioCommunications Biology2399-36422022-07-015111210.1038/s42003-022-03633-0DNA sequence-selective G-A cross-linking ADC payloads for use in solid tumour therapiesGeorge Procopiou0Paul J. M. Jackson1Daniella di Mascio2Jennifer L. Auer3Chris Pepper4Khondaker Miraz Rahman5Keith R. Fox6David E. Thurston7Femtogenix, Lawes Open Innovation Hub, Rothamsted Research, West CommonFemtogenix, Lawes Open Innovation Hub, Rothamsted Research, West CommonSchool of Biological Sciences, Life Sciences Building B85, University of SouthamptonFemtogenix, Lawes Open Innovation Hub, Rothamsted Research, West CommonBrighton and Sussex Medical School, University of SussexFemtogenix, Lawes Open Innovation Hub, Rothamsted Research, West CommonSchool of Biological Sciences, Life Sciences Building B85, University of SouthamptonFemtogenix, Lawes Open Innovation Hub, Rothamsted Research, West CommonA class of Cyclopropabenzindole-Pyridinobenzodiazepine (CBI-PDD) DNA cross-linking payloads, used in Antibody-Drug Conjugates, alkylate guanine and adenine bases in the DNA minor groove with a defined sequence selectivity.https://doi.org/10.1038/s42003-022-03633-0 |
| spellingShingle | George Procopiou Paul J. M. Jackson Daniella di Mascio Jennifer L. Auer Chris Pepper Khondaker Miraz Rahman Keith R. Fox David E. Thurston DNA sequence-selective G-A cross-linking ADC payloads for use in solid tumour therapies Communications Biology |
| title | DNA sequence-selective G-A cross-linking ADC payloads for use in solid tumour therapies |
| title_full | DNA sequence-selective G-A cross-linking ADC payloads for use in solid tumour therapies |
| title_fullStr | DNA sequence-selective G-A cross-linking ADC payloads for use in solid tumour therapies |
| title_full_unstemmed | DNA sequence-selective G-A cross-linking ADC payloads for use in solid tumour therapies |
| title_short | DNA sequence-selective G-A cross-linking ADC payloads for use in solid tumour therapies |
| title_sort | dna sequence selective g a cross linking adc payloads for use in solid tumour therapies |
| url | https://doi.org/10.1038/s42003-022-03633-0 |
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