LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins

LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins

Lipid trafficking in the brain is essential for the maintenance and repair of neuronal membranes, especially after neurotoxic insults. However, brain lipid metabolism is not completely understood. In plasma, LCAT catalyses the esterification of free cholesterol on circulating lipoproteins, a key ste...

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Bibliographic Details
Main Authors: Veronica Hirsch-Reinshagen, James Donkin, Sophie Stukas, Jennifer Chan, Anna Wilkinson, Jianjia Fan, John S. Parks, Jan Albert Kuivenhoven, Dieter Lu¨tjohann, Haydn Pritchard, Cheryl L. Wellington
Format: Article
Language:English
Published: Elsevier 2009-05-01
Series:Journal of Lipid Research
Subjects:
central nervous system
HDL
apoE
apoA-I
ABCA1
mouse
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520308415

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520308415

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