Combining HDAC and MEK Inhibitors with Radiation against Glioblastoma-Derived Spheres

Combining HDAC and MEK Inhibitors with Radiation against Glioblastoma-Derived Spheres

Glioblastoma stem-like cells (GSLCs) in glioblastoma limit effective treatment and promote therapeutic resistance and tumor recurrence. Using a combined radiation and drug-screening platform, we tested the combination of a histone deacetylase inhibitor (HDACi) and MAPK/ERK kinase inhibitor (MEKi) wi...

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Bibliographic Details
Main Authors: Eno I. Essien, Thomas P. Hofer, Michael J. Atkinson, Nataša Anastasov
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cells
Subjects:
glioblastoma
glioblastoma-derived spheres
HDAC inhibitor
MEK inhibitor
radiation
combination therapy
Online Access:https://www.mdpi.com/2073-4409/11/5/775

Internet

https://www.mdpi.com/2073-4409/11/5/775

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