Force-feeding malignant mesothelioma stem-cell like with exosome-delivered miR-126 induces tumour cell killing

Force-feeding malignant mesothelioma stem-cell like with exosome-delivered miR-126 induces tumour cell killing

Malignant pleural mesothelioma (MPM) is an aggressive tumour resistant to treatments. It has been postulated that cancer stem cells (CSCs) persist in tumours causing relapse after multimodality treatment. In the present study, a novel miRNA-based therapy approach is proposed. MPM-derived spheroids h...

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Bibliographic Details
Main Authors: Federica Monaco, Laura De Conti, Simone Vodret, Nunzia Zanotta, Manola Comar, Sandra Manzotti, Corrado Rubini, Laura Graciotti, Gianluca Fulgenzi, Massimo Bovenzi, Marco Baralle, Marco Tomasetti, Lory Santarelli
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Translational Oncology
Subjects:
Mesothelioma
miR-126
exosome
spheroids
miRNA-based therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523322000626

Internet

http://www.sciencedirect.com/science/article/pii/S1936523322000626

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