In Silico Evaluation and In Vitro Determination of Neuroprotective and MAO-B Inhibitory Effects of Pyrrole-Based Hydrazones: A Therapeutic Approach to Parkinson’s Disease

In Silico Evaluation and In Vitro Determination of Neuroprotective and MAO-B Inhibitory Effects of Pyrrole-Based Hydrazones: A Therapeutic Approach to Parkinson’s Disease

Parkinson’s disease is a huge burden in modern medicinal practice. A serious drawback of current antiparkinsonian therapy is its symptomatic nature. This directed our investigations in the search for new more potent derivatives, affecting not only the loss of dopaminergic neurons but also the oxidat...

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Bibliographic Details
Main Authors: Magdalena Kondeva-Burdina, Emilio Mateev, Borislav Angelov, Virginia Tzankova, Maya Georgieva
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
pyrrole
hydrazones
neurotoxicity and neuroprotection
MAO-B
Parkinson
Online Access:https://www.mdpi.com/1420-3049/27/23/8485

Internet

https://www.mdpi.com/1420-3049/27/23/8485

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