Thousands of CpGs Show DNA Methylation Differences in ACPA-Positive Individuals

Thousands of CpGs Show DNA Methylation Differences in ACPA-Positive Individuals

High levels of anti-citrullinated protein antibodies (ACPA) are often observed prior to a diagnosis of rheumatoid arthritis (RA). We undertook a replication study to confirm CpG sites showing evidence of differential methylation in subjects positive vs. negative for ACPA, in a new subset of 112 indi...

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Bibliographic Details
Main Authors: Yixiao Zeng, Kaiqiong Zhao, Kathleen Oros Klein, Xiaojian Shao, Marvin J. Fritzler, Marie Hudson, Inés Colmegna, Tomi Pastinen, Sasha Bernatsky, Celia M. T. Greenwood
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Genes
Subjects:
rheumatoid arthritis
anti-citrullinated protein antibody positivity
targeted bisulfite sequencing
DNA methylation
differentially methylated cytosines
differentially methylated regions
Online Access:https://www.mdpi.com/2073-4425/12/9/1349

Internet

https://www.mdpi.com/2073-4425/12/9/1349

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