FGF4 protects the liver from immune-mediated injury by activating CaMKKβ-PINK1 signal pathway to inhibit hepatocellular apoptosis

FGF4 protects the liver from immune-mediated injury by activating CaMKKβ-PINK1 signal pathway to inhibit hepatocellular apoptosis

Immune-mediated liver injury (ILI) is a condition where an aberrant immune response due to various triggers causes the destruction of hepatocytes. Fibroblast growth factor 4 (FGF4) was recently identified as a hepatoprotective cytokine; however, its role in ILI remains unclear. In patients with auto...

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Bibliographic Details
Main Authors: Zhifeng Huang, Tongtong Pan, Liang Xu, Lu Shi, Xiong Ma, Liya Zhou, Luyao Wang, Jiaojiao Wang, Guoqing Zhu, Dazhi Chen, Lingtao Song, Xiaomin Pan, Xiaodong Wang, Xiaokun Li, Yongde Luo, Yongping Chen
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Fibroblast growth factor 4
Fibroblast growth factor receptor 4
Immune liver injury
Ca2+/Calmodulin dependent protein kinase 2
PTEN-induced putative kinase 1
Mitochondria-associated apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523004811

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