Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast

Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast

Mouse embryonic stem cells (ESCs) and the inner cell mass (ICM)-derived epiblast exhibit naive pluripotency. ESC-derived epiblast stem cells (EpiSCs) and the postimplantation epiblast exhibit primed pluripotency. Although core pluripotency factors are well-characterized, additional regulators, inclu...

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Bibliographic Details
Main Authors: Dario Acampora, Daniela Omodei, Giuseppe Petrosino, Arcomaria Garofalo, Marco Savarese, Vincenzo Nigro, Luca Giovanni Di Giovannantonio, Vincenzo Mercadante, Antonio Simeone
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Cell Reports
Subjects:
Otx2
Nanog
pluripotency
embryonic stem cells
preimplantation epiblast
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716306246

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http://www.sciencedirect.com/science/article/pii/S2211124716306246

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