Nonselective and A2a-Selective Inhibition of Adenosine Receptors Modulates Renal Perfusion and Excretion Depending on the Duration of Streptozotocin-Induced Diabetes in Rats

Nonselective and A2a-Selective Inhibition of Adenosine Receptors Modulates Renal Perfusion and Excretion Depending on the Duration of Streptozotocin-Induced Diabetes in Rats

Long-lasting hyperglycaemia may alter the role of adenosine-dependent receptors (P1R) in the control of kidney function. We investigated how P1R activity affects renal circulation and excretion in diabetic (DM) and normoglycaemic (NG) rats; the receptors’ interactions with bioavailable NO and H<s...

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Bibliographic Details
Main Authors: Joanna Dorota Sitek, Marta Kuczeriszka, Agnieszka Walkowska, Elżbieta Kompanowska-Jezierska, Leszek Dobrowolski
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Pharmaceuticals
Subjects:
adenosine receptors
hyperglycaemia
hydrogen peroxide
nitric oxide
renal blood flow
renal excretion
Online Access:https://www.mdpi.com/1424-8247/16/5/732

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https://www.mdpi.com/1424-8247/16/5/732

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