The Structural Combination of SIL and MODAG Scaffolds Fails to Enhance Binding to α-Synuclein but Reveals Promising Affinity to Amyloid β

The Structural Combination of SIL and MODAG Scaffolds Fails to Enhance Binding to α-Synuclein but Reveals Promising Affinity to Amyloid β

A technique to image α-synuclein (αSYN) fibrils in vivo is an unmet scientific and clinical need that would represent a transformative tool in the understanding, diagnosis, and treatment of various neurodegenerative diseases. Several classes of compounds have shown promising results as potential PET...

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Bibliographic Details
Main Authors: Adriana Di Nanni, Ran Sing Saw, Gregory D. Bowden, Natasha S. R. Bidesi, Kaare Bjerregaard-Andersen, Špela Korat, Matthias M. Herth, Bernd J. Pichler, Kristina Herfert, Andreas Maurer
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Molecules
Subjects:
α-synuclein
positron emission tomography
PET tracer
phenothiazine
3,5-diphenylpyrazole
PD
Online Access:https://www.mdpi.com/1420-3049/28/10/4001

Internet

https://www.mdpi.com/1420-3049/28/10/4001

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