Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy

Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy

Maternal diabetes can induce neural tube defects (NTD). Here, the authors show that in mice, deletion ofPrkca(encoding protein kinase C-alpha) restores autophagy, via suppression of miR-129-2 and reversal of reduced peroxisome proliferator-activated receptor c coactivator 1alpha, so reducing NTDs.

Bibliographic Details
Main Authors: Fang Wang, Cheng Xu, E. Albert Reece, Xuezheng Li, Yanqing Wu, Christopher Harman, Jingwen Yu, Daoyin Dong, Cheng Wang, Penghua Yang, Jianxiang Zhong, Peixin Yang
Format: Article
Language:English
Published: Nature Portfolio 2017-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15182

Internet

https://doi.org/10.1038/ncomms15182

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