Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy
Maternal diabetes can induce neural tube defects (NTD). Here, the authors show that in mice, deletion ofPrkca(encoding protein kinase C-alpha) restores autophagy, via suppression of miR-129-2 and reversal of reduced peroxisome proliferator-activated receptor c coactivator 1alpha, so reducing NTDs.
Bibliographic Details
| Main Authors: |
Fang Wang,
Cheng Xu,
E. Albert Reece,
Xuezheng Li,
Yanqing Wu,
Christopher Harman,
Jingwen Yu,
Daoyin Dong,
Cheng Wang,
Penghua Yang,
Jianxiang Zhong,
Peixin Yang |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2017-05-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms15182
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