Age-Related Insulin-Like Growth Factor Binding Protein-4 Overexpression Inhibits Osteogenic Differentiation of Rat Mesenchymal Stem Cells

Age-Related Insulin-Like Growth Factor Binding Protein-4 Overexpression Inhibits Osteogenic Differentiation of Rat Mesenchymal Stem Cells

Background/Aims: Insulin-like growth factor binding proteins (IGFBP) play important roles in bone metabolism. IGFBP4 is involved in senescent-associated phenomena in mesenchymal stem cells (MSCs). The goal of the present study was to determine whether age-related IGFBP4 overexpression is associated...

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Bibliographic Details
Main Authors: Jinhui Wu, Chao Wang, Xiong Miao, Yungang Wu, Jiabin Yuan, Muchen Ding, Jingfeng Li, Zhicai Shi
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
Bone marrow-derived mesenchymal stem cells
Osteogenic differentiation
Aging
Insulin-like growth factor binding protein-4
Online Access:http://prod.karger.com/Article/FullText/477873

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http://prod.karger.com/Article/FullText/477873

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