Metformin abrogates pathological TNF-α-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome

Metformin abrogates pathological TNF-α-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome

B cells contribute to the pathogenesis of polycystic ovary syndrome (PCOS). Clinically, metformin is used to treat PCOS, but it is unclear whether metformin exerts its therapeutic effect by regulating B cells. Here, we showed that the expression level of tumor necrosis factor-alpha (TNF-α) in periph...

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Bibliographic Details
Main Authors: Na Xiao, Jie Wang, Ting Wang, Xingliang Xiong, Junyi Zhou, Xian Su, Jing Peng, Chao Yang, Xiaofeng Li, Ge Lin, Guangxiu Lu, Fei Gong, Lamei Cheng
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-06-01
Series:eLife
Subjects:
polycystic ovary syndrome
metformin
B lymphocytes
metabolic reprogramming
mechanistic target of rapamycin
Online Access:https://elifesciences.org/articles/74713

Internet

https://elifesciences.org/articles/74713

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