DNA facilitates heterodimerization between human transcription factors FoxP1 and FoxP2 by increasing their conformational flexibility

DNA facilitates heterodimerization between human transcription factors FoxP1 and FoxP2 by increasing their conformational flexibility

Summary: Transcription factors regulate gene expression by binding to DNA. They have disordered regions and specific DNA-binding domains. Binding to DNA causes structural changes, including folding and interactions with other molecules. The FoxP subfamily of transcription factors in humans is unique...

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Bibliographic Details
Main Authors: Ricardo Coñuecar, Isabel Asela, Maira Rivera, Pablo Galaz-Davison, Jorge González-Higueras, George L. Hamilton, Felipe Engelberger, César A. Ramírez-Sarmiento, Jorge Babul, Hugo Sanabria, Exequiel Medina
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:iScience
Subjects:
Biochemistry
Molecular biology
Structural biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223013056

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223013056

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