Branched-chain amino acids modulate the proteomic profile of Trypanosoma cruzi metacyclogenesis induced by proline.

Trypanosoma cruzi, the causative agent of Chagas disease, has a complex life cycle that involves triatomine insects as vectors and mammals as hosts. The differentiation of epimastigote forms into metacyclic trypomastigotes within the insect vector is crucial for the parasite's life cycle progre...

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Main Authors: Janaina de Freitas Nascimento, Flávia Silva Damasceno, Sabrina Marsiccobetre, Francisca Natália de Luna Vitorino, Renan Weege Achjian, Julia Pinheiro Chagas da Cunha, Ariel Mariano Silber
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-10-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0012588