A Systematic Review of Utilisation of Diurnal Timing Information in Clinical Trial Design for Long QT Syndrome

Diurnal oscillations in human cardiac electrophysiology are thought to be under the control of the endogenous circadian clock. The incidence of arrhythmic events in patients with Long QT syndrome (LQTS) varies diurnally. The diurnal variation in QT interval has previously been identified as a potent...

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Bibliographic Details
Main Authors: Lydia M. Seed, Timothy J. Hearn
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.867131/full