Heterosexual Transmission of Subtype C HIV-1 Selects Consensus-Like Variants without Increased Replicative Capacity or Interferon-α Resistance.

Heterosexual Transmission of Subtype C HIV-1 Selects Consensus-Like Variants without Increased Replicative Capacity or Interferon-α Resistance.

Heterosexual transmission of HIV-1 is characterized by a genetic bottleneck that selects a single viral variant, the transmitted/founder (TF), during most transmission events. To assess viral characteristics influencing HIV-1 transmission, we sequenced 167 near full-length viral genomes and generate...

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Bibliographic Details
Main Authors: Martin J Deymier, Zachary Ende, Angharad E Fenton-May, Dario A Dilernia, William Kilembe, Susan A Allen, Persephone Borrow, Eric Hunter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1005154

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https://doi.org/10.1371/journal.ppat.1005154

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