Mesenchymal and stem-like prostate cancer linked to therapy-induced lineage plasticity and metastasis

Mesenchymal and stem-like prostate cancer linked to therapy-induced lineage plasticity and metastasis

Summary: Bioinformatic analysis of 94 patient-derived xenografts (PDXs), cell lines, and organoids (PCOs) identifies three intrinsic transcriptional subtypes of metastatic castration-resistant prostate cancer: androgen receptor (AR) pathway + prostate cancer (PC) (ARPC), mesenchymal and stem-like PC...

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Main Authors: Hyunho Han, Yan Wang, Josue Curto, Sreeharsha Gurrapu, Sara Laudato, Alekya Rumandla, Goutam Chakraborty, Xiaobo Wang, Hong Chen, Yan Jiang, Dhiraj Kumar, Emily G. Caggiano, Monica Capogiri, Boyu Zhang, Yan Ji, Sankar N. Maity, Min Hu, Shanshan Bai, Ana M. Aparicio, Eleni Efstathiou, Christopher J. Logothetis, Nicholas Navin, Nora M. Navone, Yu Chen, Filippo G. Giancotti
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124722003436

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http://www.sciencedirect.com/science/article/pii/S2211124722003436

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