Specific Amino Acid Substitutions in OXA-51-Type <i>β</i>-Lactamase Enhance Catalytic Activity to a Level Comparable to Carbapenemase OXA-23 and OXA-24/40

Specific Amino Acid Substitutions in OXA-51-Type <i>β</i>-Lactamase Enhance Catalytic Activity to a Level Comparable to Carbapenemase OXA-23 and OXA-24/40

The chromosomal <i>bla</i><sub>OXA-51</sub>-type gene encodes carbapenem-hydrolyzing class D β-lactamases (CHDLs), specific variants shown to mediate carbapenem resistance in the Gram-negative bacterial pathogen <i>Acinetobacter baumannii</i>. This study aims to c...

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Bibliographic Details
Main Authors: Kwan-Wai Chan, Chen-Yu Liu, Ho-Yin Wong, Wai-Chi Chan, Kwok-Yin Wong, Sheng Chen
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
<i>A. baumannii</i>
carbapenem resistance
carbapenem-hydrolyzing class D β-lactamases (CHDLs)
OXA-51 variants
structure/function relationship
Online Access:https://www.mdpi.com/1422-0067/23/9/4496

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https://www.mdpi.com/1422-0067/23/9/4496

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