Down-Regulating HAUS6 Suppresses Cell Proliferation by Activating the p53/p21 Pathway in Colorectal Cancer

Down-Regulating HAUS6 Suppresses Cell Proliferation by Activating the p53/p21 Pathway in Colorectal Cancer

Background: HAUS6 participates in microtubule-dependent microtubule amplification, but its role in malignancies including colorectal cancer (CRC) has not been explored. We therefore assessed the potential oncogenic activities of HAUS6 in CRC.Results: HAUS6 mRNA and protein expression is higher in CR...

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Bibliographic Details
Main Authors: Aling Shen, Liya Liu, Yue Huang, Zhiqing Shen, Meizhu Wu, Xiaoping Chen, Xiangyan Wu, Xiaoying Lin, Youqin Chen, Li Li, Ying Cheng, Jianfeng Chu, Thomas J. Sferra, Lihui Wei, Qunchuan Zhuang, Jun Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
HAUS6
tumor growth
proliferation
p53/p21 pathway
survival
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.772077/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.772077/full

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