Prolyl hydroxylase domain 2 reduction enhances skeletal muscle tissue regeneration after soft tissue trauma in mice.

Prolyl hydroxylase domain 2 reduction enhances skeletal muscle tissue regeneration after soft tissue trauma in mice.

The transcription factor Hypoxia-inducible factor 1 (HIF-1) plays a pivotal role in tissue regeneration. HIF-1 is negatively controlled by O2-dependent prolyl hydroxylases with a predominant role of prolyl hydroxylase 2 isoform (Phd2). Transgenic mice, hypomorphic for this isoform, accumulate more H...

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Bibliographic Details
Main Authors: Stephan Settelmeier, Timm Schreiber, Joni Mäki, Nadiya Byts, Peppi Koivunen, Johanna Myllyharju, Joachim Fandrey, Sandra Winning
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0233261&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0233261&type=printable

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