Phenotype and Response to PAMPs of Human Monocyte-Derived Foam Cells Obtained by Long-Term Culture in the Presence of oxLDLs

Phenotype and Response to PAMPs of Human Monocyte-Derived Foam Cells Obtained by Long-Term Culture in the Presence of oxLDLs

Cholesterol-laden, foam macrophages constitute the most characteristic component of human atherosclerotic plaques. Persistent uptake of oxLDLs results in accumulation of lipid bodies inside the cells and determines their phenotype and subsequent functions. In this work, we describe the phenotype of...

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Bibliographic Details
Main Authors: Anna Nogieć, Małgorzata Bzowska, Agnieszka Demczuk, Chen Varol, Krzysztof Guzik
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
oxLDL
foam cells
macrophages
PAMPs
cytokines
atherosclerosis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01592/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01592/full

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