Brief research report: in-depth immunophenotyping reveals stability of CD19 CAR T-cells over time

Brief research report: in-depth immunophenotyping reveals stability of CD19 CAR T-cells over time

Variability or stability might have an impact on treatment success and toxicity of CD19 CAR T-cells. We conducted a prospective observational study of 12 patients treated with Tisagenlecleucel for CD19+ B-cell malignancies. Using a 31-color spectral flow cytometry panel, we analyzed differentiation...

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Bibliographic Details
Main Authors: Ivan Odak, Lâle M. Bayir, Lennart Riemann, Ruth Sikora, Jessica Schneider, Yankai Xiao, Nora Möhn, Thomas Skripuletz, Gernot Beutel, Matthias Eder, Arnold Ganser, Reinhold Förster, Christian R. Schultze-Florey, Christian Koenecke
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
CAR T-cell
DLBCL diffuse large B-cell lymphoma
ALL acute lymphoblastic leukemia
tisagenlecleucel tisa-cel
spectral flow cytometry
immunophenotyping
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1298598/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1298598/full

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