ETF-QO Mutants Uncoupled Fatty Acid β-Oxidation and Mitochondrial Bioenergetics Leading to Lipid Pathology

ETF-QO Mutants Uncoupled Fatty Acid β-Oxidation and Mitochondrial Bioenergetics Leading to Lipid Pathology

The electron-transfer flavoprotein dehydrogenase gene (<i>ETFDH</i>) that encodes the ETF-ubiquinone oxidoreductase (ETF-QO) has been reported to be the major cause of multiple acyl-CoA dehydrogenase deficiency (MADD). ETF-QO is an electron carrier that mainly functions in mitochondrial...

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Bibliographic Details
Main Authors: Suphannee Chokchaiwong, Yung-Ting Kuo, Sung-Po Hsu, Yi-Ching Hsu, Shih-Hsiang Lin, Wen-Bin Zhong, Yung-Feng Lin, Shu-Huei Kao
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cells
Subjects:
multiple acyl-CoA dehydrogenase deficiency
electron-transfer flavoprotein dehydrogenase
electron-transfer flavoprotein-ubiquinone oxidoreductase
mitochondrial dysfunction
lipid droplet accumulation
Online Access:https://www.mdpi.com/2073-4409/8/2/106

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https://www.mdpi.com/2073-4409/8/2/106

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