Modeling drug- and chemical- induced hepatotoxicity with systems biology approaches

Modeling drug- and chemical- induced hepatotoxicity with systems biology approaches

We provide an overview of computational systems biology approaches as applied to the study of chemical- and drug-induced toxicity. The concept of ‘toxicity pathways’ is described in the context of the 2007 US National Academies of Science report, Toxicity testing in the 21st Century: A Vision and A...

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Bibliographic Details
Main Authors: Sudin eBhattacharya, Lisl K.M. Shoda, Qiang eZhang, Courtney eWoods, Brett A. Howell, Scott Q. Siler, Jeffrey L. Woodhead, Yuching eYang, Patrick eMcMullen, Paul B. Watkins, Melvin E. Andersen
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-12-01
Series:Frontiers in Physiology
Subjects:
Drug Toxicity
chemical toxicity
multiscale modeling
computational toxicology
Systems toxicology
toxicity pathways
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00462/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00462/full

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