A mixture of Pueraria lobata and Platycodon grandiflorum extracts ameliorates RANKL-induced osteoclast differentiation and ovariectomy-induced bone loss by regulating Src- PI3K-AKT and JNK/p38 signaling pathways

A mixture of Pueraria lobata and Platycodon grandiflorum extracts ameliorates RANKL-induced osteoclast differentiation and ovariectomy-induced bone loss by regulating Src- PI3K-AKT and JNK/p38 signaling pathways

Osteoporosis is caused by increased bone resorption due to the excessive activity of osteoclasts. Pueraria lobata has demonstrated the ability to improve bone density in ovariectomized mice, and Platycodon grandiflorum can suppress osteolysis biomarkers such as collagen content in cartilage and alka...

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Bibliographic Details
Main Authors: Jisun Song, Suhyun Han, Sooyeon Choi, Jungkyu Lee, Yoonseon Jeong, Hyun Myung Lee, JongDai Son, Dam Yeon Jeong, Seung-Shin Yu, Wonwoo Lee
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Heliyon
Subjects:
Pueraria lobata
Platycodon grandiflorum
Herbal extracts
Osteoclast
Osteoporosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024008739

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http://www.sciencedirect.com/science/article/pii/S2405844024008739

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