Improved Effect of an Antiangiogenic Tyrosine Kinase Inhibitor (SU5416) by Combinations with Fractionated Radiotherapy or Low Molecular Weight Heparin

Improved Effect of an Antiangiogenic Tyrosine Kinase Inhibitor (SU5416) by Combinations with Fractionated Radiotherapy or Low Molecular Weight Heparin

The effect of combining SU5416 with fractionated radiotherapy or with low molecular weight (LMW) heparin (dalteparin) was studied in U87 human glioblastoma xenografts in nude mice. SU5416 is antiangiogenic by a specific inhibition of the vascular endothelial growth factor receptor 2 (VEGFR-2), hepar...

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Bibliographic Details
Main Authors: Eva L. Lund, Minna W.B. Olsen, Kenneth E. Lipson, Gerald McMahon, Anthony R. Howlett, Paul E.G. Kristjansen
Format: Article
Language:English
Published: Elsevier 2003-03-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
antiangiogenesis
heparin
fractionated radiotherapy
SU5416
glioblastoma
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558603800076

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http://www.sciencedirect.com/science/article/pii/S1476558603800076

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