In vivo effects of bradykinin B2 receptor agonists with varying susceptibility to peptidases.

In vivo effects of bradykinin B2 receptor agonists with varying susceptibility to peptidases.

We reported evidence of bradykinin (BK) regeneration from C-terminal extended BK sequences that behave as peptidase-activated B2 receptor (B2R) agonists. Further to these in vitro studies, we carried out in vivo experiments to verify hemodynamic effects of BK analogs exhibiting variable susceptibili...

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Bibliographic Details
Main Authors: Mélissa eJean, Lajos eGera, Xavier eCharest-Morin, François eMarceau, Hélène eBachelard
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Pharmacology
Subjects:
Bradykinin
Hypotension
Blood flow
angiotensin converting enzyme
arginine carboxypeptidases
B2 receptors
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00306/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00306/full

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