Discovery of Phenylcarbamoylazinane-1,2,4-Triazole Amides Derivatives as the Potential Inhibitors of Aldo-Keto Reductases (AKR1B1 & AKRB10): Potential Lead Molecules for Treatment of Colon Cancer

Discovery of Phenylcarbamoylazinane-1,2,4-Triazole Amides Derivatives as the Potential Inhibitors of Aldo-Keto Reductases (AKR1B1 & AKRB10): Potential Lead Molecules for Treatment of Colon Cancer

Both members of the aldo-keto reductases (AKRs) family, AKR1B1 and AKR1B10, are over-expressed in various type of cancer, making them potential targets for inflammation-mediated cancers such as colon, lung, breast, and prostate cancers. This is the first comprehensive study which focused on the iden...

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Bibliographic Details
Main Authors: Amna Saeed, Syeda Abida Ejaz, Muhammad Sarfraz, Nissren Tamam, Farhan Siddique, Naheed Riaz, Faizan Abul Qais, Samir Chtita, Jamshed Iqbal
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
aldose reductase
molecular docking
density functional theory
ADMET properties
AutoDock tools
Molecular Operating Environment
Online Access:https://www.mdpi.com/1420-3049/27/13/3981

Internet

https://www.mdpi.com/1420-3049/27/13/3981

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