Uncovering the mechanisms of MuRF1-induced ubiquitylation and revealing similarities with MuRF2 and MuRF3

Uncovering the mechanisms of MuRF1-induced ubiquitylation and revealing similarities with MuRF2 and MuRF3

MuRF1 (Muscle-specific RING finger protein 1; gene name TRIM63) is a ubiquitin E3 ligase, associated with the progression of muscle atrophy. As a RING (Really Interesting New Gene) type E3 ligase, its unique activity of ubiquitylation is driven by a specific interaction with a UBE2 (ubiquitin conjug...

ver descrição completa

Detalhes bibliográficos
Principais autores: Samuel O. Lord, Peter W.J. Dawson, Jitpisute Chunthorng-Orn, Jimi Ng, Leslie M. Baehr, David C. Hughes, Pooja Sridhar, Timothy Knowles, Sue C. Bodine, Yu-Chiang Lai
Formato: Artigo
Idioma:English
Publicado em: Elsevier 2024-03-01
coleção:Biochemistry and Biophysics Reports
Assuntos:
RING E3 Ligase
Ubiquitin Conjugating Enzyme (UBE2)
Ubiquitin
Autoubiquitylation
In vitro
Muscle Atrophy
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2405580823002170

Internet

http://www.sciencedirect.com/science/article/pii/S2405580823002170

Registros relacionados