Analytical Performance of Next-Generation Sequencing and RT-PCR on Formalin-Fixed Paraffin-Embedded Tumor Tissues for <i>PIK3CA</i> Testing in HR+/HER2− Breast Cancer

Analytical Performance of Next-Generation Sequencing and RT-PCR on Formalin-Fixed Paraffin-Embedded Tumor Tissues for <i>PIK3CA</i> Testing in HR+/HER2− Breast Cancer

Somatic mutations in <i>PIK3CA</i> are present in ~40% breast cancers (BC); their detection in hormone receptor (HR)+/HER2− tumors allows for selecting patients with advanced disease eligible for <i>PIK3CA</i> targeting with alpelisib. The choice of what type of <i>PIK3...

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Bibliographic Details
Main Authors: Konstantinos Venetis, Francesco Pepe, Elisabetta Munzone, Elham Sajjadi, Gianluca Russo, Pasquale Pisapia, Mariia Ivanova, Giuseppina Bonizzi, Davide Vacirca, Alessandra Rappa, Alberto Ranghiero, Sergio Vincenzo Taormina, Giuseppe Viale, Giancarlo Troncone, Massimo Barberis, Elena Guerini-Rocco, Umberto Malapelle, Nicola Fusco
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
breast cancer
biomarkers
<i>PIK3CA</i>
NGS
RT-PCR
Online Access:https://www.mdpi.com/2073-4409/11/22/3545

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https://www.mdpi.com/2073-4409/11/22/3545

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