Fibroblast growth factors (FGFs) prime the limb specific Shh enhancer for chromatin changes that balance histone acetylation mediated by E26 transformation-specific (ETS) factors

Fibroblast growth factors (FGFs) prime the limb specific Shh enhancer for chromatin changes that balance histone acetylation mediated by E26 transformation-specific (ETS) factors

Sonic hedgehog (Shh) expression in the limb bud organizing centre called the zone of polarizing activity is regulated by the ZRS enhancer. Here, we examine in mouse and in a mouse limb-derived cell line the dynamic events that activate and restrict the spatial activity of the ZRS. Fibroblast growth...

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Bibliographic Details
Main Authors: Silvia Peluso, Adam Douglas, Alison Hill, Carlo De Angelis, Benjamin L Moore, Graeme Grimes, Giulia Petrovich, Abdelkader Essafi, Robert E Hill
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-09-01
Series:eLife
Subjects:
histone acetylation
ETS factors
Shh
ZRS
Enhancer
Online Access:https://elifesciences.org/articles/28590

Internet

https://elifesciences.org/articles/28590

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