BMAL1-TTK-H2Bub1 loop deficiency contributes to impaired BM-MSC-mediated bone formation in senile osteoporosis

BMAL1-TTK-H2Bub1 loop deficiency contributes to impaired BM-MSC-mediated bone formation in senile osteoporosis

During the aging process, the reduced osteogenic differentiation of bone marrow mesenchymal stem cells (BM-MSCs) results in decreased bone formation, which contributes to senile osteoporosis. Previous studies have confirmed that interrupted circadian rhythm plays an indispensable role in age-related...

Full description

Bibliographic Details
Main Authors: Li Jinteng, Xu Peitao, Yu Wenhui, Ye Guiwen, Ye Feng, Xu Xiaojun, Su Zepeng, Lin Jiajie, Che Yunshu, Zhang Zhaoqiang, Zeng Yipeng, Li Zhikun, Feng Pei, Cao Qian, Li Dateng, Xie Zhongyu, Wu Yanfeng, Shen Huiyong
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and Applications
senile osteoporosis
mesenchymal stem cells
BMAL1
histone H2B monoubiquitination
rAAV9 therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123000343

Internet

http://www.sciencedirect.com/science/article/pii/S2162253123000343

Similar Items