Increased circulating uric acid aggravates heart failure via impaired fatty acid metabolism

Increased circulating uric acid aggravates heart failure via impaired fatty acid metabolism

Abstract Background Increased circulating uric acid (UA) concentration may disrupt cardiac function in heart failure patients, but the specific mechanism remains unclear. Here, we postulate that hyperuremia induces sterol regulatory element binding protein 1 (SREBP1), which in turn activate hepatic...

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Bibliographic Details
Main Authors: Bowen Lou, Haoyu Wu, Hannes Ott, Katrin Bennewitz, Chen Wang, Gernot Poschet, Hui Liu, Zuyi Yuan, Jens Kroll, Jianqing She
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Translational Medicine
Subjects:
Uric acid
Fatty acid
Sterol regulatory element binding proteins 1
Heart failure
Online Access:https://doi.org/10.1186/s12967-023-04050-5

Internet

https://doi.org/10.1186/s12967-023-04050-5

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